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Estradiol is the most potent form of naturally occurring estrogen in the human body. It is a steroid hormone that is essential for the development and maintenance of female sex characteristics.

Where does estradiol come from?

Estradiol is produced primarily by the ovaries, adrenal glands, and fat tissues in women. It is also produced in small amounts in men by the testes and adrenal glands.

What are the functions of estradiol?

  • Promotes the development of female secondary sex characteristics during puberty, such as breast growth, widening of hips, and menstrual cycles
  • Regulates the menstrual cycle and prepares the body for pregnancy
  • Maintains bone density and cardiovascular health
  • Affects the brain and influences behaviors

How do estrogen levels change over a woman's lifespan?

  • Puberty: Estradiol levels rise, triggering breast development, growth spurts, and the start of menstruation.
  • Menstrual years: Estradiol levels fluctuate cyclically to control the menstrual cycle. Levels peak just before ovulation.
  • Pregnancy: High levels of estradiol help maintain pregnancy and promote fetal development.
  • Menopause: Ovarian production of estradiol declines substantially leading up to and after menopause. This causes hot flashes, vaginal dryness, and bone loss.

When are abnormal estradiol levels a concern?

Abnormally high or low levels of estradiol can indicate certain medical conditions:

  • High estradiol may indicate ovarian tumors or polycystic ovary syndrome (PCOS)
  • Low estradiol is concerning for primary ovarian insufficiency, pituitary issues, or premature ovarian failure
  • Fluctuating estradiol outside a normal range may require medical attention

Let me know if you have any other questions! Estradiol is an essential hormone, especially for biological females. Monitoring your levels with your doctor at Thrive Hormone Therapy can help identify reproductive or endocrine issues early on.

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